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ea0029p1034 | Male Reproduction | ICEECE2012

G protein-coupled estrogen receptor 1- and estrogen receptor α-dependent pathways regulate spermatocytes apoptosis

Chimento A. , Sirianni R. , Casaburi I. , Ruggiero C. , Maggiolini M. , Ando S. , Pezzi V.

In mammals, spontaneous apoptosis is observed particularly in differentiating spermatogonia and spermatocytes. We have previously demonstrated that 17β-estradiol (E2) in primary rat pachytene spermatocytes (PS) binds ESR1 and GPER1 to activate EGFR/ERK/c-Jun pathway leading to up regulation of bax, a pro-apoptotic factor. Aim of this study was to clarify the effector pathway(s) controlling spermatocytes apoptosis using as model GC-2 cells, an immortalized mouse...

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ea0029oc9.3 | Endocrine Tumours & Translation | ICEECE2012

The central role of estrogen receptor α in IGF2 dependent adrenocortical carcinoma (ACC) cell proliferation suggests the use of selective estrogen receptor modulators (SERMs) for the treatment of ACC

Sirianni R. , Chimento A. , De Luca A. , Cerquetti L. , Carpinelli G. , Fallo F. , Pilon C. , Arnaldi G. , Stigliano A. , Pezzi V.

Adrenocortical Cancer (ACC) is characterized by an increased production of insulin-like growth factor 2 (IGF2) and by estrogen receptor (ER) α up-regulation. Aim of this study was to define IGF2 and estrogen signaling interactions in ACC, in order to give new indications for a better therapy. To this aim we used H295R cells and human ACC tissues which display common features: IGF2 activation of downstream effector pathways and over-expression of estrogen-related genes inc...

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Endocrine Abstracts

G protein-coupled estrogen receptor 1- and estrogen receptor α-dependent pathways regulate spermatocytes apoptosis

The central role of estrogen receptor α in IGF2 dependent adrenocortical carcinoma (ACC) cell proliferation suggests the use of selective estrogen receptor modulators (SERMs) for the treatment of ACC

BiosciAbstracts